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Betty C. Jung's Web site 2010
http://www.bettycjung.net/index.htm
bcj17@columbia.edu or, bettycjung@yahoo.com


(Posted August 16, 2010) "....more than half of men and 70% of women age 50 to 79 in the U.S. exceed the abdominal obesity threshold -- 88 cm or around 35 inches for women and 102 cm or 40 inches for men. Having a large waist circumference increases the risk of death -- even for people who are not overweight,... For women with a normal BMI, each 10 cm/3.9 inch increase in girth increased their risk of dying by 25% compared with heavier women... a larger waist is also associated with inflammation, insulin resistance, type 2 diabetes, dyslipidemia, and coronary heart disease -- all independently of BMI The associations with waist circumference were strongest for mortality caused by respiratory disease, followed by cardiovascular disease and then cancer."; "•Women who were overweight only as adults had a RR of 8.23 for diabetes, whereas those who were overweight at age 10 years and as adults had an RR of 15.10. •Women who were overweight at age 10 years but became lean as adults did not have an increased risk for type 2 diabetes. •Weight loss of 10 lbs or more during adulthood was associated with a reduced risk for diabetes among women who were overweight or obese but not among women who were lean."; "Visceral fat is important because it is recognized as an independent predictor of the metabolic syndrome, diabetes, and cardiovascular disease in women."; "obese patients with knee osteoarthritis who lost substantial weight showed signs of structural improvement in their damaged joints."; "Sarcopenia — low skeletal muscle mass and strength — is often found in obese people and older adults; puts individuals at risk for developing Type 2 diabetes...associated with insulin resistance..., with high blood-sugar levels in obese people but not in thin people. Dieting to be thin is on its own not enough to stave off diabetes. It is also important to be fit and, in particular, to have good muscle mass and strength."; "More than 44 million Americans will have diabetes within 25 years under current trends, and the annual cost of caring for them will triple to $336 billion in constant 2007 dollars,...The obesity epidemic, ever-earlier ages of diabetes onset, and increasing longevity of people with established diabetes are combining to enlarge the diabetic population far beyond anything envisioned in earlier projections."; "Diabetes is responsible for more deaths each year in the United States than breast cancer and AIDS combined, but just 42 percent of those surveyed knew that diabetes could be so deadly.Those in the high-risk category include people who are older than 45, are of a race other than white or have a family history of the disease. Being physically inactive or overweight are also risk factors for type 2 diabetes."; "Diabetes is, in part, an inflammatory condition. Proinflammatory mechanisms have been linked to the core metabolic defects of beta-cell insufficiency and insulin resistance. Diabetes is an important risk factor for cardiovascular disease. Known therapies that do reduce cardiovascular events...include exercise; weight management; smoking cessation; blood pressure control; and, in appropriate patients, antiplatelet and statin therapy."; "Restrictive rather than obstructive impairment of lung function is associated with incident T2DM (and fatal CHD) with both associations partially explained by traditional and metabolic risk factors and inflammation,"; "Treating serious gum disease in diabetics can help to lower their blood sugar levels,...Dental treatment to reduce this inflammation may therefore help to reduce blood sugar levels."; "Higher intake of white rice (≥ 5 servings per week vs < 1 per month) was associated with a greater risk for type 2 diabetes. Substituting brown rice or other whole grains for white rice is associated with a lower risk for type 2 diabetes,...;" "Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes....diabetics deficient in vitamin D can't process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke. When people are deficient in vitamin D, the macrophage cells eat more cholesterol, and they can't get rid of it. The macrophages get clogged with cholesterol and become what scientists call foam cells, which are one of the earliest markers of atherosclerosis."; "Type-2 diabetes can be prevented through structured lifestyle changes...moderate weight loss and increased physical activity reduced the risk of developing type-2 diabetes by 60 percent."

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